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S Club 7 were an English pop group from London created by former Spice Girls manager Simon Fuller consisting of members Bradley McIntosh, Hannah Spearritt, Jo O'Meara, Jon Lee, Paul Cattermole, Rachel Stevens and Tina Barrett.

S'Express (pronounced ess-express) were an English dance music act from the late 1980s, who had one of the earliest commercial successes in the acid house genre.

Aaron Jerome, known professionally as Sbtrkt, (pronounced "subtract") is an English musician and producer.

Bridie Monds-Watson, better known by her stage name SOAK, is a Northern Irish singer-songwriter born in Derry in 1996.

SOB X RBE (an acronym of Strictly Only Brothers x Real Boi Entertainment) is an American hip hop group.

Christopher Michael Taylor, professionally known as Sohn (stylised as SOHN), is an English singer, songwriter and record producer.

SOJA is an American Grammy-nominated reggae band based in Arlington, Virginia.

Stéphanie Alexandra Mina Sokolinski (born 26 October 1985), known professionally as Soko, is a French singer-songwriter, musician and actress.

SWMRS (formerly Emily's Army), pronounced 'swimmers', is an American punk rock band formed in Piedmont, California in 2004 by Cole Becker and Joey Armstrong, with Becker's brother Max Becker joining only a few weeks afterwards.

SWV (Sisters With Voices) is an American R&B vocal trio from New York City, New York whose members are Cheryl (Coko) Gamble, Tamara (Taj) Johnson and Leanne (Lelee) Lyons.

Solána Imani Rowe (born November 8, 1990), known professionally as SZA, is an American singer and songwriter.

Sabrina Claudio (born September 19, 1996) is an American singer and songwriter.