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Sleaford Mods are an English electronic punk music duo formed in 2007 in Nottingham.

Sleater-Kinney, formed in 1994, is an influential American rock band known for feminist values. With Corin Tucker and Carrie Brownstein, their work spans eras, celebrated by critics. "Little Rope" (2024) showcases their enduring impact, solidifying their status as pioneering rock icons.

Sleeping at Last is a musical project led by singer-songwriter and multi-instrumentalist Ryan O'Neal.

Sleeping with Sirens is an American rock band from Orlando, Florida currently residing in Grand Rapids, Michigan.

Sleigh Bells is an American noise rock musical duo based in Brooklyn, New York, formed in 2008.

Richard Martin Lloyd Walters (born January 14, 1965), better known as Slick Rick, is a British-born American rapper and record producer who was raised in The Bronx, New York.

Slightly Stoopid is an American band based in the Ocean Beach neighborhood of San Diego, California, who describe their music as "a fusion of folk, rock, reggae and blues with hip-hop, funk, metal and punk".

Slipknot is an American heavy metal band from Des Moines, Iowa.

Sly and the Family Stone was an American band from San Francisco.

Smash Mouth is an American rock band from San Jose, California.

The Smashing Pumpkins (or Smashing Pumpkins) are an American alternative rock band from Chicago.

Smoke Fairies (Katherine Blamire and Jessica Davies) are a British band hailing from Chichester.