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Santana is an American rock band formed in San Francisco in 1966 by Mexican-American guitarist and songwriter Carlos Santana.

Santi White (born September 25, 1976), known professionally as Santigold (formerly Santogold), is an American singer, songwriter and record producer.

Saosin is an American rock band formed in Orange County, California in 2003.

Sara Beth Bareilles (born December 7, 1979) is an American singer-songwriter and actress.

Sara Lynn Evans (born February 5, 1971) is an American country music singer and songwriter.

Sarah Brightman (born 14 August 1960) is an English classical crossover soprano, singer, songwriter, actress, dancer and musician.

Sarah Connor (born Sarah Marianne Corina Lewe; June 13, 1980) is an American-German singer, songwriter, and dancer.

Sarah Ann Darling (born October 4, 1982) is an American country music singer and songwriter.

Sarah Ann McLachlan (born January 28, 1968) is a Canadian singer-songwriter known for her emotional ballads and mezzo-soprano vocal range.

Sash! (stylised as SASH!) is a German DJ/production team, fronted by Sascha Lappessen (born 10 June 1970) who works in the recording studio with Ralf Kappmeier and Thomas "Alisson" Lüdke.

Savage Garden was an Australian pop duo consisting of Darren Hayes on vocals and Daniel Jones on instruments.

Saving Abel is an American rock band from Corinth, Mississippi, founded in 2004 by Jared Weeks and Jason Null.