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Semisonic is an American alternative rock band formed in Minneapolis, Minnesota in 1995.

Senses Fail is an American post-hardcore band that formed in Ridgewood, New Jersey in 2002.

Sepultura is a Brazilian heavy metal band from Belo Horizonte.

Serena Lauren Ryder (born December 8, 1982) is a Canadian singer-songwriter. Born in Toronto, she grew up in Millbrook, Ontario.

Serj Tankian (born August 21, 1967) is an Armenian American musician, singer, songwriter, multi-instrumentalist, record producer, poet and political activist.

Set It Off is an American rock band that started in Tampa, Florida.

Seth Bernard Lakeman (born 26 March 1977) is an English folk singer, songwriter, and multi-instrumentalist, who is most often associated with the fiddle and tenor guitar, but also plays the viola and banjo.

Seven Mary Three, (occasionally abbreviated to 7 Mary 3 or 7M3) were an American rock band. They released seven studio albums and one live album, and are best known for their hit single "Cumbersome".

Sevendust is an American rock band from Atlanta, Georgia, formed in 1994 by bassist Vince Hornsby, drummer Morgan Rose and guitarist John Connolly.

Amber Denise "Sevyn" Streeter (born July 7, 1986) is an American singer and songwriter, best known for being a member of the girl groups TG4 and RichGirl where she was known as Se7en. She signed to Atlantic Records and released her debut single "I Like It" in 2012.

The Sex Pistols were an English punk rock band that formed in London in 1975.

Shadows Fall is an American heavy metal band from Springfield, Massachusetts, formed in 1995.